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Table 3 Associations of baseline Western Ontario and McMaster Universities Osteoarthritis Index knee pain score with annual percentage cartilage volume loss and incidence and progression of radiographic knee osteoarthritis over 4 years

From: Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

 

Univariable analysis

Multivariable analysisa

Non-ROA

 

Regression coefficient (95% CI)

p Value

Regression coefficient (95% CI)

p Value

Annual percentage cartilage volume loss in medial compartment

0.04 (0.01, 0.06)

0.001

0.04 (0.02, 0.06)

0.001

Annual percentage cartilage volume loss in lateral compartment

0.04 (0.02, 0.06)

< 0.001

0.04 (0.02, 0.06)

< 0.001

 

OR (95% CI)

p Value

OR (95% CI)

p Value

Incidence of radiographic knee osteoarthritis

1.10 (1.05, 1.16)

< 0.001

1.07 (1.01, 1.13)

0.02

ROA

 

Regression coefficient (95% CI)

p Value

Regression coefficient (95% CI)

p Value

Annual percentage cartilage volume loss in medial compartment

0.06 (0.03, 0.08)

< 0.001

0.04 (0.02, 0.07)

0.001

Annual percentage cartilage volume loss in lateral compartment

0.06 (0.04, 0.08)

< 0.001

0.05 (0.03, 0.07)

< 0.001

 

OR (95% CI)

p Value

OR (95% CI)

p Value

Progression of radiographic knee osteoarthritis

1.08 (1.05, 1.12)

< 0.001

1.07 (1.03, 1.10)

< 0.001

  1. ROA Radiographic osteoarthritis
  2. aAdjusted for age, gender, body mass index and Kellgren-Lawrence grade