Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

Table 3 Associations of baseline Western Ontario and McMaster Universities Osteoarthritis Index knee pain score with annual percentage cartilage volume loss and incidence and progression of radiographic knee osteoarthritis over 4 years

	Univariable analysis		Multivariable analysis^a
Non-ROA
	Regression coefficient (95% CI)	p Value	Regression coefficient (95% CI)	p Value
Annual percentage cartilage volume loss in medial compartment	0.04 (0.01, 0.06)	0.001	0.04 (0.02, 0.06)	0.001
Annual percentage cartilage volume loss in lateral compartment	0.04 (0.02, 0.06)	< 0.001	0.04 (0.02, 0.06)	< 0.001
	OR (95% CI)	p Value	OR (95% CI)	p Value
Incidence of radiographic knee osteoarthritis	1.10 (1.05, 1.16)	< 0.001	1.07 (1.01, 1.13)	0.02
ROA
	Regression coefficient (95% CI)	p Value	Regression coefficient (95% CI)	p Value
Annual percentage cartilage volume loss in medial compartment	0.06 (0.03, 0.08)	< 0.001	0.04 (0.02, 0.07)	0.001
Annual percentage cartilage volume loss in lateral compartment	0.06 (0.04, 0.08)	< 0.001	0.05 (0.03, 0.07)	< 0.001
	OR (95% CI)	p Value	OR (95% CI)	p Value
Progression of radiographic knee osteoarthritis	1.08 (1.05, 1.12)	< 0.001	1.07 (1.03, 1.10)	< 0.001