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Table 3 Associations of baseline Western Ontario and McMaster Universities Osteoarthritis Index knee pain score with annual percentage cartilage volume loss and incidence and progression of radiographic knee osteoarthritis over 4 years

From: Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

  Univariable analysis Multivariable analysisa
Non-ROA
  Regression coefficient (95% CI) p Value Regression coefficient (95% CI) p Value
Annual percentage cartilage volume loss in medial compartment 0.04 (0.01, 0.06) 0.001 0.04 (0.02, 0.06) 0.001
Annual percentage cartilage volume loss in lateral compartment 0.04 (0.02, 0.06) < 0.001 0.04 (0.02, 0.06) < 0.001
  OR (95% CI) p Value OR (95% CI) p Value
Incidence of radiographic knee osteoarthritis 1.10 (1.05, 1.16) < 0.001 1.07 (1.01, 1.13) 0.02
ROA
  Regression coefficient (95% CI) p Value Regression coefficient (95% CI) p Value
Annual percentage cartilage volume loss in medial compartment 0.06 (0.03, 0.08) < 0.001 0.04 (0.02, 0.07) 0.001
Annual percentage cartilage volume loss in lateral compartment 0.06 (0.04, 0.08) < 0.001 0.05 (0.03, 0.07) < 0.001
  OR (95% CI) p Value OR (95% CI) p Value
Progression of radiographic knee osteoarthritis 1.08 (1.05, 1.12) < 0.001 1.07 (1.03, 1.10) < 0.001
  1. ROA Radiographic osteoarthritis
  2. aAdjusted for age, gender, body mass index and Kellgren-Lawrence grade