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Table 5 Associations of knee pain patterns over 1 year with annual percentage cartilage volume loss and progression of radiographic knee osteoarthritis over 4 years in participants with radiographic knee osteoarthritis at baseline

From: Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

  Univariable analysis Multivariable analysisa
Estimated marginal mean (SE) p Value Estimated marginal mean (SE) p Value
Annual percentage cartilage volume loss in medial compartment
 No knee pain at both baseline and 1 year 1.22 (0.06)   1.26 (0.06)b  
 Fluctuating knee pain (pain at either time point) 1.52 (0.11) 0.001c 1.47 (0.11) 0.03c
 Persistent knee pain (pain at both time points) 1.68 (0.12)   1.60 (0.12)b  
 Trend   < 0.001   0.01
Annual percentage cartilage volume loss in lateral compartment
 No knee pain at both baseline and 1 year 1.06 (0.05)   1.08 (0.05)d,e  
 Fluctuating knee pain (pain at either time point) 1.41 (0.08) < 0.001c 1.38 (0.08)d < 0.001c
 Persistent knee pain (pain at both time points) 1.46 (0.09)   1.39 (0.09)e  
 Trend   < 0.001   < 0.001
  Odds ratio (95% CI) p Value Odds ratio (95% CI) p Value
Progression of radiographic knee osteoarthritis
 No knee pain at both baseline and 1 year 1.00   1.00  
 Fluctuating knee pain (pain at either time point) 1.46 (1.04, 2.06) 0.03 1.34 (0.94, 1.89) 0.10
 Persistent knee pain (pain at both time points) 2.13 (1.53, 2.97) < 0.001 1.82 (1.28, 2.60) 0.001
 Trend   < 0.001   0.001
  1. *Adjusted for age, gender, body mass index and Kellgren-Lawrence grade
  2. bp = 0.02 for between-group difference
  3. c For difference in annual percentage cartilage volume loss in medial/lateral compartment among the three knee pain pattern groups
  4. dp = 0.001 for between-group difference
  5. ep = 0.002 for between-group difference