Table 5 Associations of knee pain patterns over 1 year with annual percentage cartilage volume loss and progression of radiographic knee osteoarthritis over 4 years in participants with radiographic knee osteoarthritis at baseline

 No knee pain at both baseline and 1 year

1.22 (0.06)

1.26 (0.06)^b

 Fluctuating knee pain (pain at either time point)

1.52 (0.11)

0.001^c

1.47 (0.11)

0.03^c

 Persistent knee pain (pain at both time points)

1.68 (0.12)

1.60 (0.12)^b

 Trend

< 0.001

0.01

 No knee pain at both baseline and 1 year

1.06 (0.05)

1.08 (0.05)^d,e

 Fluctuating knee pain (pain at either time point)

1.41 (0.08)

< 0.001^c

1.38 (0.08)^d

< 0.001^c

 Persistent knee pain (pain at both time points)

1.46 (0.09)

1.39 (0.09)^e

 Trend

< 0.001

< 0.001

Odds ratio (95% CI)

p Value

Odds ratio (95% CI)

p Value

 No knee pain at both baseline and 1 year

1.00

1.00

 Fluctuating knee pain (pain at either time point)

1.46 (1.04, 2.06)

0.03

1.34 (0.94, 1.89)

0.10

 Persistent knee pain (pain at both time points)

2.13 (1.53, 2.97)

< 0.001

1.82 (1.28, 2.60)

0.001

 Trend

< 0.001

0.001