Fig. 2

Altered expression of interleukin (IL)-23-regulated microRNAs (miRNAs) in T cells from patients with ankylosing spondylitis (AS) and from healthy control subjects. a Expression profiles of miRNAs in K562 cells cocultured with or without IL-23 (20 ng/ml) for 3 days, evaluated using microarray analysis. Each scatter spot represents the mean raw signals of miRNA in three repeats of each treatment. b The expression levels of 12 miRNAs were significantly higher, whereas the expression levels of 4 miRNAs were significantly lower, in K562 cells after coculture with IL-23 for 3 days (P < 0.05). c Increased expression of miR-29b-1-5p, miR-4449, miR-211-3p, miR-1914-3p, and miR-7114-5p in AS T-cell miRNA, compared with normal T cells after validation