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Table 2 Diagnostic statistics of dichotomized biomarkers

From: Calprotectin strongly and independently predicts relapse in rheumatoid arthritis and polyarticular psoriatic arthritis patients treated with tumor necrosis factor inhibitors: a 1-year prospective cohort study

  Calprotectin TNFi trough serum levels Power Doppler score
Cut-off level to predict relapse ≥ 3.7 μg/mL < 1.61 μg/mL ≥ 4
Area under the curve 1.000 (1.000–1.000) 0.790 (0.691–0.889) 0.877 (0.772–0.981)
Sensitivity 100% 68.7% 75.0%
Specificity 98.8% 83.3% 89.2%
Positive likelihood ratio 83.0 4.12 6.92
Negative likelihood ratio 0.00 0.37 0.28
Correctly classified 98.9% 70.5% 87.4%
Youden index 0.99 0.51 0.64
  1. TNFi tumor necrosis factor inhibitors