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Table 2 Diagnostic statistics of dichotomized biomarkers

From: Calprotectin strongly and independently predicts relapse in rheumatoid arthritis and polyarticular psoriatic arthritis patients treated with tumor necrosis factor inhibitors: a 1-year prospective cohort study

 

Calprotectin

TNFi trough serum levels

Power Doppler score

Cut-off level to predict relapse

≥ 3.7 μg/mL

< 1.61 μg/mL

≥ 4

Area under the curve

1.000 (1.000–1.000)

0.790 (0.691–0.889)

0.877 (0.772–0.981)

Sensitivity

100%

68.7%

75.0%

Specificity

98.8%

83.3%

89.2%

Positive likelihood ratio

83.0

4.12

6.92

Negative likelihood ratio

0.00

0.37

0.28

Correctly classified

98.9%

70.5%

87.4%

Youden index

0.99

0.51

0.64

  1. TNFi tumor necrosis factor inhibitors