Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort

Table 3 Risk of developing uveitis in relation to 25(OH)D level (mean of both measurements) and other parameters

	Patients with uveitis n = 61	Patients without uveitis n = 299	Hazard ratio	95% CI	p value
25(OH)D level, mean (SD), ng/ml	21.0 (6.8)	22.4 (8.0)	0.95	0.91; 0.99	0.022
Female sex, n (%)	45 (74)	198 (66)	1.32	2.56; 0.68	0.414
Age at JIA onset, mean (SD), years	4.0 (2.9)	7.8 (4.6)	0.84	0.77; 0.93	0.001
Oligoarticular JIA onset, n (%)	41 (67)	132 (44)	1.20	0.60; 2.41	0.601
ANA positivity at study inclusion, n (%)	58 (95)	170 (57)	5.07	1.50; 17.15	0.009
cJADAS-10^a (range 0–30), mean (SD)	5.9 (3.9)	4.8 (3.2)	1.22	1.14; 1.31	< 0.001
MTX treatment^b, n (%)	31 (51)	235 (79)	0.29	0.15; 0.57	< 0.001

25(OH)D 25(OH) vitamin D, JIA juvenile idiopathic arthritis, ANA antinuclear antibodies, MTX methotrexate, cJADAS Clinical Juvenile Arthritis Disease Activity Score
^acJADAS-10: mean score in patients with uveitis were calculated until occurrence of uveitis, in patients without uveitis mean cJADAS-10 score was calculated until 3-year follow up
^bMTX: patients with uveitis, ever treated with MTX until occurrence of uveitis; patients without uveitis, ever treated until 3-year follow up

ISSN: 1478-6362