Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis

Table 1 Immune cells subsets in MRL/lpr mice

	MRL/lpr control mice	MRL/lpr + SSR treatment
Spleen: absolute cell numbers (×10⁶)
Total cells	174.1 ± 16.8	88.90 ± 17.06**
Total T cells (CD3⁺)	63.15 ± 9.14	40.75 ± 19.97
CD3⁺ CD4⁺ cells	9.51 ± 1.13	5.04 ± 0.81**
CD3⁺ CD8⁺ cells	2.67 ± 0.75	1.56 ± 0.61
CD3⁺ CD4⁺ CD69⁺ cells	2.56 ± 1.28	1.76 ± 0.21
CD3⁺ CD4⁺ foxp3 cells	0.97 ± 0.21	0.59 ± 0.32
Total B cells (B220⁺)	104.5 ± 25.82	47.85 ± 16.62*
B220⁺ CD21^highCD23^low cells	11.82 ± 1.86	5.94 ± 1.29**
B220⁺ CD23^highCD21^low cells	6.48 ± 1.85	10.34 ± 6.31
CD11b⁺ F4/80⁺ CD86⁺ cells	1.80 ± 0.23	1.10 ± 0.74
CD11c⁺ CD86⁺ cells	9.72 ± 1.65	6.54 ± 2.50
Kidney: absolute cell numbers (×10⁵)
Total cells	27.16 ± 5.73	18.97 ± 1.22
Total infiltrating cells (CD45⁺)	6.92 ± 1.63	4.75 ± 1.61
CD45⁺ CD3⁺ CD4⁺ cells	1.57 ± 0.29	0.91 ± 0.18*
CD45⁺ CD3⁺ CD4⁺ foxp3 cells	0.18 ± 0.05	0.17 ± 0.04
CD45⁺ CD11b⁺ F4/80⁺ cells	3.06 ± 1.27	1.04 ± 0.12*
CD45⁺ CD11c⁺ cells	3.52 ± 2.07	1.96 ± 0.94
CD45⁺ CD11b⁺ Gr-1⁺ cells	0.43 ± 0.07	0.20 ± 0.006*

ISSN: 1478-6362