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Table 2 Comparison of biomarkers between patients with immunoglobulin G4-related disease and healthy controls

From: Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

  IgG4-RD n = 72 Healthy controls n = 44 P value
GDF-15, pg/mL 1121 (680–1839) 362 (191–433) <0.0001
CCL2, pg/mL 357 (268–449) 300 (219–349) 0.016
TIMP-1, ng/mL 183 (156–260) 143 (127–163) <0.0001
HA, ng/mL 78.1 (43.6–121) 22.6 (13.9–43.6) <0.0001
PIIINP, ng/mL 27.2 (14.5–50.4) 5.8 (0.4–23.0) <0.0001
ELF score 10.4 (9.8–11.2) 8.4 (4.6–9.5) <0.0001
  1. The data are median (interquartile range, Q1/4–Q3/4). Within-group comparisons were assessed with the Mann–Whitney U test. Abbreviations: CCL2 CC chemokine ligand 2, ELF enhanced liver fibrosis, GDF-15 growth differentiation factor 15, HA hyaluronic acid, IgG4-RD immunoglobulin G4-related disease, PIIINP amino-terminal propeptide of type III procollagen, TIMP-1 tissue inhibitor of metalloproteinases 1