Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

Kawashiri, Shin-ya; Origuchi, Tomoki; Umeda, Masataka; Nishino, Ayako; Shimizu, Toshimasa; Fukui, Shoichi; Koga, Tomohiro; Iwamoto, Naoki; Ichinose, Kunihiro; Tamai, Mami; Nakamura, Hideki; Maeda, Takahiro; Kawano, Mitsuhiro; Yamamoto, Motohisa; Izumi, Yasumori; Kawakami, Atsushi

doi:10.1186/s13075-018-1777-7

Table 3 Correlations between each biomarker in patients with immunoglobulin G4-related disease

From: Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

	GDF-15		CCL2		TIMP-1		HA		PIIINP		ELF score		Total-IgG		IgG4		CH50		C3		C4		sIL2R
	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value	rs	P value
GDF-15	–	–	0.48	<0.0001	0.62	<0.0001	0.61	<0.0001	0.13	0.27	0.51	<0.0001	0.37	0.0013	0.12	0.33	−0.24	0.061	−0.38	0.0016	−0.34	0.0049	0.47	0.0002
CCL2	0.48	<0.0001	–	–	0.50	<0.0001	0.47	<0.0001	−0.031	0.80	0.35	0.0032	0.13	0.10	0.12	0.33	−0.14	0.31	−0.25	0.0085	−0.22	0.085	0.35	0.0064
TIMP-1	0.62	<0.0001	0.50	<0.0001	–	–	0.29	0.015	0.06	0.64	0.36	0.0021	0.25	0.036	0.10	0.43	−0.35	0.005	−0.21	0.095	−0.21	0.095	0.43	0.0007
HA	0.61	<0.0001	0.47	<0.0001	0.29	0.015	–	–	0.06	0.64	0.65	<0.0001	0.30	0.011	0.18	0.14	−0.18	0.17	−0.23	0.069	−0.24	0.055	0.26	0.051
PIIINP	0.13	0.27	−0.31	0.80	0.06	0.64	0.06	0.64	–	–	0.72	<0.0001	0.02	0.89	−0.02	0.87	−0.12	0.34	−0.18	0.16	−0.12	0.33	0.04	0.74
ELF score	0.51	<0.0001	0.35	0.0032	0.36	0.0021	0.65	<0.0001	0.72	<0.0001	–	–	0.24	0.044	0.09	0.44	−0.10	0.43	−0.21	0.084	−0.18	0.16	0.22	0.098
Total-IgG	0.37	0.0013	0.13	0.28	0.25	0.036	0.30	0.011	0.02	0.89	0.24	0.044	–	–	0.74	<0.0001	−0.34	0.0067	−0.43	0.0003	−0.40	0.001	0.69	<0.0001
IgG4	0.12	0.33	0.12	0.33	0.10	0.43	0.18	0.14	−0.02	0.87	0.09	0.44	0.74	<0.0001	–	–	−0.29	0.023	−0.40	0.0009	−0.37	0.0025	0.60	<0.0001
CH50	−0.24	0.061	−0.14	0.31	−0.35	0.005	−0.18	0.17	−0.12	0.34	−0.10	0.43	−0.34	0.0067	−0.29	0.023	–	–	0.56	<0.0001	0.66	<0.0001	−0.50	0.0003
C3	−0.38	0.0016	−0.25	0.051	−0.21	0.084	−0.23	0.069	−0.18	0.16	−0.21	0.084	−0.43	0.0003	−0.4	0.0009	0.56	<0.0001	–	–	0.73	<0.0001	−0.54	0.0002
C4	−0.34	0.0049	−0.22	0.085	−0.21	0.095	−0.24	0.055	−0.12	0.33	−0.18	0.16	−0.40	0.001	−0.37	0.0025	0.66	<0.0001	0.73	<0.0001	–	–	−0.39	0.0038
sIL-2R	0.47	0.0002	0.35	0.0064	0.43	0.0007	0.26	0.051	0.04	0.74	0.22	0.098	0.69	<0.0001	0.60	<0.0001	−0.50	0.0003	−0.54	0.0002	−0.39	0.0038	–	–

The results were obtained using Spearman’s correlation coefficient. Abbreviations: CCL2 CC chemokine ligand 2, ELF enhanced liver fibrosis, GDF-15 growth differentiation factor 15, HA hyaluronic acid, IgG4-RD immunoglobulin G4-related disease, PIIINP amino-terminal propeptide of type III procollagen, sIL-2R soluble interleukin-2 receptor, TIMP-1 tissue inhibitor of metalloproteinases 1

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