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Table 3 Correlations between each biomarker in patients with immunoglobulin G4-related disease

From: Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

  GDF-15 CCL2 TIMP-1 HA PIIINP ELF score Total-IgG IgG4 CH50 C3 C4 sIL2R
rs P value rs P value rs P value rs P value rs P value rs P value rs P value rs P value rs P value rs P value rs P value rs P value
GDF-15 0.48 <0.0001 0.62 <0.0001 0.61 <0.0001 0.13 0.27 0.51 <0.0001 0.37 0.0013 0.12 0.33 −0.24 0.061 −0.38 0.0016 −0.34 0.0049 0.47 0.0002
CCL2 0.48 <0.0001 0.50 <0.0001 0.47 <0.0001 −0.031 0.80 0.35 0.0032 0.13 0.10 0.12 0.33 −0.14 0.31 −0.25 0.0085 −0.22 0.085 0.35 0.0064
TIMP-1 0.62 <0.0001 0.50 <0.0001 0.29 0.015 0.06 0.64 0.36 0.0021 0.25 0.036 0.10 0.43 −0.35 0.005 −0.21 0.095 −0.21 0.095 0.43 0.0007
HA 0.61 <0.0001 0.47 <0.0001 0.29 0.015 0.06 0.64 0.65 <0.0001 0.30 0.011 0.18 0.14 −0.18 0.17 −0.23 0.069 −0.24 0.055 0.26 0.051
PIIINP 0.13 0.27 −0.31 0.80 0.06 0.64 0.06 0.64 0.72 <0.0001 0.02 0.89 −0.02 0.87 −0.12 0.34 −0.18 0.16 −0.12 0.33 0.04 0.74
ELF score 0.51 <0.0001 0.35 0.0032 0.36 0.0021 0.65 <0.0001 0.72 <0.0001 0.24 0.044 0.09 0.44 −0.10 0.43 −0.21 0.084 −0.18 0.16 0.22 0.098
Total-IgG 0.37 0.0013 0.13 0.28 0.25 0.036 0.30 0.011 0.02 0.89 0.24 0.044 0.74 <0.0001 −0.34 0.0067 −0.43 0.0003 −0.40 0.001 0.69 <0.0001
IgG4 0.12 0.33 0.12 0.33 0.10 0.43 0.18 0.14 −0.02 0.87 0.09 0.44 0.74 <0.0001 −0.29 0.023 −0.40 0.0009 −0.37 0.0025 0.60 <0.0001
CH50 −0.24 0.061 −0.14 0.31 −0.35 0.005 −0.18 0.17 −0.12 0.34 −0.10 0.43 −0.34 0.0067 −0.29 0.023 0.56 <0.0001 0.66 <0.0001 −0.50 0.0003
C3 −0.38 0.0016 −0.25 0.051 −0.21 0.084 −0.23 0.069 −0.18 0.16 −0.21 0.084 −0.43 0.0003 −0.4 0.0009 0.56 <0.0001 0.73 <0.0001 −0.54 0.0002
C4 −0.34 0.0049 −0.22 0.085 −0.21 0.095 −0.24 0.055 −0.12 0.33 −0.18 0.16 −0.40 0.001 −0.37 0.0025 0.66 <0.0001 0.73 <0.0001 −0.39 0.0038
sIL-2R 0.47 0.0002 0.35 0.0064 0.43 0.0007 0.26 0.051 0.04 0.74 0.22 0.098 0.69 <0.0001 0.60 <0.0001 −0.50 0.0003 −0.54 0.0002 −0.39 0.0038
  1. The results were obtained using Spearman’s correlation coefficient. Abbreviations: CCL2 CC chemokine ligand 2, ELF enhanced liver fibrosis, GDF-15 growth differentiation factor 15, HA hyaluronic acid, IgG4-RD immunoglobulin G4-related disease, PIIINP amino-terminal propeptide of type III procollagen, sIL-2R soluble interleukin-2 receptor, TIMP-1 tissue inhibitor of metalloproteinases 1