Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

Table 4 Correlations between the immunoglobulin G4-related disease responder index score or the number of organ involvements and the biomarkers

	IgG4-RD responder index		Number of organ involvements
	rs	P value	rs	P value
GDF-15	0.11	0.35	0.07	0.54
CCL2	0.07	0.56	0.03	0.81
TIMP-1	0.11	0.36	0.10	0.42
HA	0.17	0.16	0.17	0.15
PIIINP	−0.19	0.10	−0.17	0.16
ELF score	−0.07	0.58	−0.04	0.73
IgG	0.49	<0.0001	0.43	0.0002
IgG4	0.64	<0.0001	0.61	<0.0001
CH50	−0.21	0.10	−0.24	0.063
C3	−0.27	0.029	−0.28	0.022
C4	−0.33	0.0066	−0.35	0.0043
sIL-2R	0.52	<0.0001	0.51	<0.0001

The results were obtained using Spearman’s correlation coefficient. Abbreviations: CCL2 CC chemokine ligand 2, ELF enhanced liver fibrosis, GDF-15 growth differentiation factor 15, HA hyaluronic acid, IgG4-RD immunoglobulin G4-related disease, PIIINP amino-terminal propeptide of type III procollagen, sIL-2R soluble interleukin-2 receptor, TIMP-1 tissue inhibitor of metalloproteinases 1

ISSN: 1478-6362