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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Fig. 4

Kv1.3 and KCa1.1 blockers synergize to reduce disease severity in collagen-induced arthritis (CIA). a Clinical scores of rats with CIA treated with vehicle (open squares), iberiotoxin (IbTX; black triangles), ShK-186 (gray squares), or both IbTX and ShK-186 (open triangles) every other day (EOD) starting at disease onset. Data are presented as mean ± SEM (n = 11 or 12 rats per group). b Left: X-rays of hind paws from a healthy rat and from rats with CIA treated with vehicle, IbTX, ShK-186, or both IbTX and ShK-186 EOD for 14 days after disease onset. Center and right: Safranin O/Fast Green staining (center) and H&E staining (right) of tissue sections of hind paw joints of a healthy rat and of rats in each treatment group. Arrows indicate areas of cartilage erosions (Safranin O/Fast Green) or hyperplasia (H&E). Scale bar = 100 μm. c Scoring of disease parameters from tissue sections of paws from rats of each treatment group (n = 3 rats per group). *p < 0.05, ****p < 0.0001

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