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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Fig. 6

Fibroblast-like synoviocytes (FLS) from collagen-induced arthritis (CIA) rats treated with potassium channel blockers have reduced pathogenic phenotypes ex vivo. a Invasion through Matrigel-coated Transwell inserts of FLS isolated from healthy rats or from rats with CIA treated with either vehicle, ShK-186, iberiotoxin (IbTX), or ShK-186 and IbTX every other day (EOD) for 14 days after disease onset. Data are presented as mean ± SEM (n = 3 FLS donors per group). b KCa1.1α expression by FLS isolated from healthy rats and from rats with CIA treated with vehicle, ShK-186, IbTX, or ShK-186 and IbTX EOD for 14 days after disease onset. Data are presented as mean ± SEM (n = 5 FLS donors per group). c Data from (b) plotted against the clinical scores on the 14th day after disease onset of the rats with CIA from which the FLS were isolated, along with a linear regression plot. *p < 0.05, **p < 0.01

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