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Table 3 Multivariate regression analysis for knee OA at 2-year and/or 5-year follow up according to the ACR classification criteria (n = 64, 35 cases, a priori risk = 0.55)

From: Prevalence and development of hip and knee osteoarthritis according to American College of Rheumatology criteria in the CHECK cohort

Baseline characteristics Analysis per category OR (95% CI) Multivariate analysis OR (95% CI) PPV NPV LR+ LR-
Demographics
 Age (<=50 vs. > 50 years) 0.37 (0.13–1.36) 0.42 (0.14–1.06) 0.39 0.37 0.53 1.44
Complaints and symptoms
 Morning stiffness knee (yes = 1/no = 0) 6.79 (0.65–51.23) 6.08 (0.53–69.93) 0.86 0.49 4.97 0.08
Physical examination
 Joint line tenderness 1.05 (0.21–5.14) 1.92 (0.34–10.79) 0.73 0.5 2.2 0.8
Diagnostic tests
 ESR < 20 mm/h 0.94 (0.87–1.02) 0.94 (0.85–1.03) na na na na
  1. OR odds ratio, PPV positive predictive value, NPV negative predictive value, NRS numeric rating scale, ESR erythrocyte sedimentation rate, LR+ positive likelihood ratio, LR- negative likelihood ratio, na not applicable (continuous variable)
  2. p < 0.05