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Table 1 Baseline characteristics of participants according to overall group and sex

From: Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank

 All patients
n = 359,876
Women
n = 188,221
Men
n = 171,655
Men vs women (gout cases)
P
Control
n = 352,534
Gout
n = 7342
Control
n = 187,647
Gout
n = 574
Control
n = 164,887
Gout
n = 6768
Age, years (SD)56.9 (8.0)60.0 (6.9)56.8 (7.9)61.8 (5.9)57.0 (8.1)59.8 (6.9)2.90 × 10−11
BMI, kg/m2 (SD)27.2 (4.6)30.7 (4.9)26.8 (5.0)32.3 (6.6)27.6 (4.1)30.6 (4.8)7.13 × 10−16
Smoker, n (%)*35,768 (10.2%)661 (9.0%)16,006 (8.6%)59 (10.3%)19,762 (12.0%)602 (8.9%)0.34
Alcohol frequency, n (%)*
 Daily or almost daily74,318 (21.1%)2475 (33.7%)31,696 (16.9%)90 (15.7%)42,622 (25.9%)2385 (35.3%)8.12 × 10−102
 One to four times a week85,226 (24.2%)2026 (27.6%)40,499 (21.6%)86 (15.0%)44,727 (27.1%)1940 (28.7%)
 Once or twice a week93,145 (26.4%)1668 (22.7%)49,718 (26.5%)130 (22.7%)43,427 (26.4%)1538 (22.7%)
 Infrequent**76,172 (21.6%)838 (11.4%)50,509 (26.9%)178 (31.0%)25,663 (15.5%)660 (9.8%)
 Never23,442 (6.7%)327 (4.5%)15,108 (8.1%)89 (15.5%)8334 (5.1%)238 (3.5%)
Diuretic use, n (%)*28,722 (8.1%)1210 (16.5%)16,031 (8.5%)206 (35.9%)12,691 (7.7%)1004 (14.8%)6.05 × 10−39
Co-morbidities, n (%)*
 Hypercholesterolaemia42,929 (16.7%)2056 (28.2%)18,322 (13.4%)180 (31.6%)24,607 (20.5%)1876 (27.9%)0.06
 Hypertension89,575 (34.9%)4161 (57.0%)42,152 (30.8%)364 (63.9%)47,423 (39.5%)3797 (56.4%)5.95 × 10−4
 Peripheral vascular disease616 (0.2%)10 (0.1%)358 (0.3%)4 (0.7%)258 (0.2%)6 (0.1%)1.47 × 10−4
 Angina11,265 (4.4%)662 (9.1%)3603 (2.6%)59 (10.4%)7662 (6.4%)603 (9.0%)0.27
 Myocardial infarction8261 (3.2%)521 (7.1%)1604 (1.2%)25 (4.4%)6657 (5.5%)496 (7.4%)0.01
 Heart failure196 (0.1%)44 (0.6%)73 (0.1%)5 (0.9%)123 (0.1%)39 (0.6%)0.38
 Arrhythmia1952 (0.8%)71 (1.0%)950 (0.7%)3 (0.5%)1002 (0.8%)68 (1.0%)0.26
 Stroke4733 (1.8%)254 (3.5%)1895 (1.4%)31 (5.4%)2838 (2.4%)223 (3.3%)0.01
 Transient ischaemic attack1343 (0.5%)59 (0.8%)623 (0.5%)5 (0.9%)720 (0.6%)54 (0.8%)0.85
 Renal failure443 (0.1%)108 (1.5%)222 (0.1%)18 (3.1%)221 (0.1%)90 (1.3%)5.59 × 10−4
 Diabetes mellitus16,108 (6.3%)1005 (13.8%)5846 (4.3%)110 (19.3%)10,262 (8.5%)895 (13.3%)0.01
  1. BMI body mass index, SD standard deviation
  2. *Smoking status, alcohol frequency, medication use and co-morbidity data collected via self-report
  3. ** Infrequent alcohol frequency defined as one to three times a month, or special occasions only