Table 2 Association and interaction between serum urate-associated single nucleotide polymorphisms and sex for gout risk
Gene | SNP | Effect allele | Women n = 188,221 | Men n = 171,655 | Gene-sex interaction P | ||
|---|---|---|---|---|---|---|---|
Effect allele absent Referent OR | Effect allele present OR (95% CI) | Effect allele absent OR (95% CI) | Effect allele present OR (95% CI) | ||||
Loci replicated by Kottgen | |||||||
ABCG2 | rs2231142 | T | 1 | 1.62 (1.35–1.94) | 11.99 (10.81–13.30) | 28.65 (25.73–31.90) | 4.59 × 10−5 |
SLC2A9 | rs12498742 | A | 1 | 4.12 (2.05–8.30) | 18.09 (8.85–36.98) | 55.62 (27.77–111.37) | 0.42 |
GCKR | rs1260326 | T | 1 | 1.42 (1.18–1.70) | 13.80 (11.77–16.18) | 19.08 (16.33–22.29) | 0.80 |
SLC17A3 | rs1165151 | T | 1 | 0.76 (0.64–0.91) | 13.15 (11.38–15.20) | 10.56 (9.16–12.17) | 0.60 |
SLC22A12 | rs478607 | A | 1 | 0.78 (0.48–1.28) | 13.96 (8.44–23.09) | 10.57 (6.53–17.11) | 0.90 |
PDZK1 | rs1471633 | A | 1 | 0.92 (0.77–1.10) | 10.54 (9.00–12.34) | 13.61 (11.68–15.85) | 3.67 × 10−4 |
INHBE | rs3741414 | T | 1 | 0.82 (0.69–0.98) | 13.57 (12.16–15.15) | 11.06 (9.89–12.38) | 0.92 |
SLC16A9 | rs1171614 | T | 1 | 0.95 (0.80–1.12) | 14.28 (12.78–15.96) | 11.74 (10.48–13.16) | 0.11 |
SLC22A11 | rs2078267 | T | 1 | 0.78 (0.65–0.95) | 13.59 (11.42–16.17) | 10.57 (8.93–12.51) | 0.96 |
RREB1 | rs675209 | T | 1 | 1.23 (1.04–1.45) | 14.28 (12.62–16.16) | 15.74 (13.90–17.82) | 0.23 |
Loci reported by Kottgen | |||||||
PKLR | rs11264341 | T | 1 | 0.82 (0.69–0.97) | 13.09 (11.4–15.08) | 11.34 (9.87–13.02) | 0.57 |
INHBB | rs17050272 | A | 1 | 1.10 (0.93–1.32) | 14.25 (12.26–16.57) | 14.54 (12.54–16.85) | 0.40 |
ACVR2A | rs2307394 | T | 1 | 0.99 (0.75–1.31) | 14.72 (11.13–19.48) | 13.28 (10.14–17.40) | 0.53 |
MUSTN1 | rs6770152 | T | 1 | 0.96 (0.78–1.19) | 15.29 (12.50–18.70) | 12.75 (10.49–15.51) | 0.21 |
TMEM171 | rs17632159 | C | 1 | 0.76 (0.65–0.90) | 12.81 (11.39–14.41) | 11.31 (10.06–12.73) | 0.11 |
VEGFA | rs729761 | T | 1 | 0.99 (0.84–1.17) | 13.89 (12.29–15.70) | 13.03 (11.53–14.74) | 0.55 |
MLXIPL | rs1178977 | A | 1 | 1.71 (1.00–2.90) | 17.96 (10.42–30.95) | 22.86 (13.50–38.72) | 0.30 |
PRKAG2 | rs10480300 | T | 1 | 0.97 (0.82–1.15) | 12.74 (11.31–14.35) | 14.07 (12.50–15.85) | 0.15 |
STC1 | rs17786744 | A | 1 | 1.36 (1.06–1.74) | 17.59 (13.86–22.33) | 17.64 (13.99–22.25) | 0.02 |
HNF4G | rs2941484 | T | 1 | 1.11 (0.92–1.33) | 14.00 (11.89–16.49) | 14.78 (12.59–17.34) | 0.62 |
ASAH2 | rs10821905 | A | 1 | 0.96 (0.80–1.15) | 12.86 (11.57–14.29) | 14.63 (13.12–16.33) | 0.07 |
LTBP3 | rs642803 | T | 1 | 0.92 (0.77–1.10) | 13.81 (11.80–16.16) | 12.33 (10.58–14.38) | 0.76 |
PTPN11 | rs653178 | T | 1 | 0.85 (0.70–1.02) | 13.30 (11.24–15.74) | 11.52 (9.78–13.57) | 0.82 |
NRG4 | rs1394125 | A | 1 | 1.02 (0.86–1.21) | 13.06 (11.40–14.98) | 14.17 (12.38–16.21) | 0.52 |
IGF1R | rs6598541 | A | 1 | 1.06 (0.89–1.25) | 13.05 (11.38–14.96) | 14.48 (12.65–16.56) | 0.59 |
NFAT5 | rs7193778 | T | 1 | 1.12 (0.63–1.98) | 20.20 (11.23–36.35) | 14.91 (8.44–26.35) | 0.17 |
MAF | rs7188445 | A | 1 | 0.96 (0.82–1.14) | 13.64 (12.01–15.48) | 12.91 (11.38–14.65) | 0.84 |
HLF | rs7224610 | A | 1 | 0.90 (0.72–1.12) | 13.76 (11.13–17.00) | 12.13 (9.89–14.89) | 0.88 |
C17ORF82 | rs2079742 | T | 1 | 0.92 (0.52–1.64) | 10.34 (5.65–18.93) | 12.54 (7.09–22.19) | 0.38 |
PRPSAP1 | rs164009 | A | 1 | 1.32 (1.02–1.71) | 17.00 (13.25–21.82) | 17.27 (13.55–22.01) | 0.05 |