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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Fig. 1

Long-term inhibition of arachidonic acid and prostaglandin E2 (PGE2) release in synoviocytes. a Inhibition of arachidonic acid (AA) release by AVX001 and AVX002 in synoviocytes in response to IL-1β (10 ng/mL). #p ≤ 0.001 vs. IL-1β, ^p ≤ 0.001 vs. AVX001. b IL-1β, AVX001 and AVX002 do not affect oleic acid (OA) release. c AVX001 and AVX002 reduce PGE2 synthesis following 24 h stimulation with IL-1β (10 ng/mL). #p ≤ 0.001 vs. control (Ctrl); *p ≤ 0.05 vs. IL-1β; **p ≤ 0.001 vs. IL-1β. Results shown are average ± SD of 2–4 experiments analyzed in duplicates. HRS, hours

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