Fig. 2

Effect of the cytosolic phospholipase A2 protein (cPLA2α) inhibitors AVX001 and AVX002 on arthritis index (AI). a AVX001 and AVX002 delay and reduce arthritis progression as efficiently as methotrexate (MTX) in a prophylactic collagen-induced arthritis (CIA) model (n = 11). b AVX001 and AVX002 reduce the AI in a manner comparable to Enbrel in a therapeutic CIA model (n = 10). *p < 0.05, **p < 0.01, ^#p < 0.005 vs. vehicle, ^{^}p < 0.01 vs. AVX001 at study termination. Red arrows mark collagen II challenge; blue arrows mark start of treatment