Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Fig. 3

Effects of Cytosolic phospholipase A2 protein (cPLA2α) inhibitors on histopathology analysis. a AVX001 and AVX002 reduce arthritis and joint damage more efficiently than methotrexate (MTX) in the prophylactic collagen-induced arthritis (CIA) model. Histopathology analysis was performed on hind paws from mice killed at day 33. b AVX001 and AVX002 reduce arthritis and joint damage more efficiently than Enbrel in the therapeutic CIA model. Histopathology analysis was performed on hind paws from mice killed at day 41. *p < 0.05, **p < 0.01, #p < 0.005 vs. vehicle; error bars denote standard error of mean (n = 3–4). c Representative histology analysis depicting overall joint structure in naïve, vehicle-treated and treated mice at study termination, day 41 (therapeutic study) (HE stain of paraffin sections, × 100). PGE2, prostaglandin E2

Back to article page