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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Fig. 4

Effect of treatment on plasma prostaglandin E2 (PGE2). a In the prophylactic collagen-induced arthritis (CIA) study, AVX001 (10 mg/kg body weight (BW)) and AVX002 (10 and 30 mg/kg BW) significantly reduce plasma PGE2, comparable to the effect of methotrexate (MTX) (0.3 mg/kg); error bars denote standard deviation (n = 11). B) In the therapeutic CIA study, AVX001 and AVX002 (30 mg/kg BW) also significantly reduce plasma PGE2, whereas Enbrel (25 mg/kg BW) did not significantly reduce PGE2 (n = 10). *p < 0.05 and **p < 0.005 vs. vehicle, #p < 0.001 vs. naïve

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