The oncoprotein TBX3 is controlling severity in experimental arthritis

Table 2 Anti-collagen type II antibody levels in serum of Eae39r2 sub-congenic mice

Congenic fragment	Days after collagen type II immunization	Antibody isotype	Antibody titers in groups of mice (AU/ml)^a		Statistics^b
Congenic fragment	Days after collagen type II immunization	Antibody isotype	Homozygous Congenic	Littermate controls	p value
Eae39r2	15 (preclinical phase)	IgG₁	252 ± 46	96 ± 26	0.0041**
		IgG_2C	148 ± 11	77 ± 10	< 0.0001****
		IgG₃	7 ± 0.5	4 ± 0.3	0.0067**
		IgM	55 ± 3	37 ± 4	0.0002***
	72 (clinical phase)	IgG₁	5044 ± 1363	1852 ± 486	0.0002***
		IgG_2C	822 ± 113	323 ± 45	< 0.0001****
		IgG₃	9 ± 0.5	5 ± 0.4	< 0.0001****
		IgM	11 ± 4	9 ± 3	0.144

^aArbitrary units per ml (AU/ml) are calculated in comparison to a standard curve of pooled serum from arthritic mice in the same experiment
^bData were analyzed using the Mann-Whitney U test; *p < 0.05, **p < 0.01, ***p < 0.001

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