Table 3 Genetic elements located in the Eae39r2 region, their expression, and literature overview
From: The oncoprotein TBX3 is controlling severity in experimental arthritis
Genetic Elementa | Expressionb | Literature summary |
|---|---|---|
Tbx3 (+) | Expressed in colon, lung, heart, liver, adrenal gland and spleen | Controls cell proliferation and differentiation [37, 60, 62]; enhances tumor invasiveness [18]; regulates gene splicing [68]; modulates number of cell signaling pathways involved in the development of limb, mammary gland, and heart [18]; regulates bone formation [69, 70] and bone resorption [71]; downregulated in the early phase of collagen-induced arthritis (CIA) [21]; linked to rheumatoid arthritis (RA) in a genome-wide association study (GWAS) [72]; and modulated in RA twin lymphoblastoid B cell lines compared with healthy co-twin LCLs [73]. |
Tbx5 (+) | Expressed in heart, lung, bone, and urinary bladder | Controls cell proliferation, differentiation and migration [74, 75]; involved in cell signaling pathways [76,77,78]; regulates bone growth and maturation [20, 79] and system development [80, 81]; downregulated in the early phase of CIA [21]; linked to osteochondrosis in GWAS [82] and RA by activation of RA synovial fibroblasts [83]. |
Rbm19 (+) | Expressed in heart, lung, uterus, and skeletal muscle | Key role in synthesis of the small eukaryotic ribosome subunit [84], pre-implantation development [13], and mammary gland morphology [85]. |
1700081H04Rik (+) | Expressed in testis, brain, heart, kidney and liver | No data available |
n-R5s175 (+) | Expressed in kidney, liver, testis, brain, spleen, skeletal tissue, and lung | No data available |
Tbx3os1 (−) | Expressed in liver, lung, colon, brain, kidney, skeletal muscle, spleen, and testis | No data available |
Gm16063 (+) | Expressed in liver, lung, colon, brain, kidney, skeletal muscle, spleen, and testis | No data available |
Gm16064 (+) | Expressed in colon, kidney, lung, spleen, brain, liver, skeletal muscle, and testis | No data available |
Tbx3os2 (−) | Expressed in kidney, lung, brain, colon, liver, adrenal gland, and spleen | No data available |
Gm10390 (−) | Expressed in brain, liver, spleen, testis, heart, skeletal muscle, colon, and lung | No data available |