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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Fig. 3

MAIT cells hyporesponsive upon fixed Escherichia coli stimulation in early untreated RA patients. PBMCs stimulated overnight by fixed E. coli (MOI = 6). CD25 (a) and CD69 (b) upregulation used as a proxy for activation. a Basal expression of CD25 relatively low and comparable in all groups. Stimulation by fixed E. coli induced upregulation of CD25 in controls (median MFI = 177) and SpA patients (median MFI = 95.15). RA MAIT cells barely responded to fixed E. coli stimulation (median CD25 MFI = 0). b Basal expression of CD69 lower in RA patients (median RA MFI = 196.5 vs control MFI = 495.7 vs SpA MFI = 405.1). Fixed E. coli stimulation clearly increased CD69 expression in controls (median MFI = 1307) and SpA patients (median MFI = 1257). CD69 upregulation in RA patients was significantly lower compared to controls and SpA (median RA MFI = 466.6). *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. MAIT mucosal-associated invariant T, MFI mean fluorescence intensity, RA rheumatoid arthritis, SpA spondyloarthritis

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