Fig. 1

Elevated levels of cell-free DNA and NET-DNA complexes in the circulation of patients with active AOSD. a The concentration of cell-free DNA, citrullinated histone 3 (citH3)-DNA, neutrophil elastase (NE)-DNA, and myeloperoxidase (MPO)-DNA complexes in the sera of patients with adult-onset Still’s disease (AOSD; n = 73) or healthy controls (HC; n = 40) were determined using PicoGreen. b Correlation of sera cell-free DNA with citH3-DNA, NE-DNA, and MPO-DNA complexes was analyzed. c Levels of sera cell-free DNA, citH3-DNA, NE-DNA, and MPO-DNA complexes in AOSD patients with active disease and inactive disease were measured using PicoGreen. d Reduced levels of cell-free DNA, citH3-DNA, NE-DNA, and MPO-DNA complexes in 11 AOSD patients after treatment. The results show the means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001