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Table 2 Test characteristics of the different available tests detecting disease activity in our granulomatosis with polyangiitis cohort, using Birmingham Vasculitis Activity Score version 3 as gold standard, with Birmingham Vasculitis Activity Score ≥ 3 reflecting active disease

From: IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

  ESR CRP ANCA titer Physician VAS qPCR test
Sensitivity (%) 50 92 73 80 86
Specificity (%) 100 69 38 90 100
Positive predictive value (%) 100 73 52 86 100
Negative predictive value (%) 77 90 60 86 91
  1. Abbreviations: ANCA Antineutrophil cytoplasmic antibodies, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, VAS Visual analogue scale
  2. The cutoff values used were 30 mm/h for ESR, 5 mg/L for CRP, 7 kIU/L for ANCA, 2 or higher for physician VAS, and 11.2% for the qPCR test