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Table 3 Overview of six individuals tested while suspected of having granulomatosis with polyangiitis flare

From: IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

Identifier CS1 CS2 E A2 A1 B
Cohort CS CS L L L L
Age, years 59 64 63 65 64 53
Dominant organ at presentation CNS Lungs Lungs Lungs ENT Eyes
ESR 13 NA 20 NA 38 2
CRP NA 74.2 1.3 128.1 44.5 10.6
ANCA 1.3 NA 264 74.5 114.9 NA
Outcome Radiculopathy Community-acquired pneumonia Streptococcus pneumoniae pneumonia Influenza A pneumonia GPA GPA
BVAS (in case of GPA)      7 6
qPCR score 1.5% 0.9% 1.3% 3.3% 29.3% 18.8%
  1. Abbreviations: ANCA Antineutrophil cytoplasmic antibodies, BVAS Birmingham Vasculitis Activity Score, CNS Central Nervous System, CRP C-reactive protein, CS Cross-sectional, ESR Erythrocyte sedimentation rate, GPA Granulomatosis with polyangiitis, L Longitudinal, NA Not annotated at visit
  2. Two columns at right highlight the individuals in whom the suspicion turned out to be true. Identifiers for the CS patients were randomly assigned for this overview’s purposes. Identifiers for L patients match the identifiers in Fig. 3