IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

Table 3 Overview of six individuals tested while suspected of having granulomatosis with polyangiitis flare

Identifier	CS1	CS2	E	A2	A1	B
Cohort	CS	CS	L	L	L	L
Age, years	59	64	63	65	64	53
Dominant organ at presentation	CNS	Lungs	Lungs	Lungs	ENT	Eyes
ESR	13	NA	20	NA	38	2
CRP	NA	74.2	1.3	128.1	44.5	10.6
ANCA	1.3	NA	264	74.5	114.9	NA
Outcome	Radiculopathy	Community-acquired pneumonia	Streptococcus pneumoniae pneumonia	Influenza A pneumonia	GPA	GPA
BVAS (in case of GPA)					7	6
qPCR score	1.5%	0.9%	1.3%	3.3%	29.3%	18.8%

Abbreviations: ANCA Antineutrophil cytoplasmic antibodies, BVAS Birmingham Vasculitis Activity Score, CNS Central Nervous System, CRP C-reactive protein, CS Cross-sectional, ESR Erythrocyte sedimentation rate, GPA Granulomatosis with polyangiitis, L Longitudinal, NA Not annotated at visit
Two columns at right highlight the individuals in whom the suspicion turned out to be true. Identifiers for the CS patients were randomly assigned for this overview’s purposes. Identifiers for L patients match the identifiers in Fig. 3

ISSN: 1478-6362