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Table 3 Estimation of MCID estimates in mRSS using SF-36 health transition anchor for all participants

From: Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II)

Change in mRSS by level of anchors—SF-36 health transition item N Unadjusted mean Effect size
Mean 95% LCL 95% UCL
Overall
 Much better (1) 50 − 5.64 − 7.31 − 3.97 − 0.53
 Somewhat better (2) (MCID estimate for improvement) 35 − 2.86 − 4.94 − 0.78 − 0.27
 Same (3) 67 − 2.72 − 3.96 − 1.48 − 0.25
 Somewhat worse (4) 32 − 1.66 − 4.04 0.73 − 0.15
 Much worse (5) 3 − 4.67 − 20.64 11.3 − 0.44
Diffuse SSc
 Much better (1) 35 − 7.66 − 9.64 − 5.67 − 0.80
 Somewhat better (2) (MCID estimate for improvement) 23 − 4.70 − 7.38 − 2.01 − 0.49
 Same (3) 36 − 4.61 − 6.56 − 2.66 − 0.48
 Somewhat worse (4) 20 − 2.25 − 6.12 1.62 − 0.23
 Much worse (5) 1 − 12.00    
Limited SSc
 Much better (1) 15 − 0.93 − 2.28 0.41 − 0.26
 Somewhat better (2) (MCID estimate for improvement) 12 0.67 − 1.82 3.15 0.19
 Same (3) 31 − 0.52 − 1.61 0.58 − 0.14
 Somewhat worse (4) 12 − 0.67 − 1.76 0.43 − 0.19
 Much worse (5) 2 − 1.00 − 13.71 11.71 − 0.28
  1. LCL lower confidence limit, MCID minimal clinically important difference, mRSS modified Rodnan Skin Score, SF-36 Short Form-36, SSc systemic sclerosis, UCL upper confidence limit