Fig. 3
Distribution of the SSc skin core microbiome. The distribution and relative abundance of the SSc skin core microbiome was calculated by rarefaction to the depth of the lowest sample, and filtering to retain the fewest taxa necessary to account for 90% of all reads, resulting in a total of 103 unique genera. Data were then log2-transformed and median centered by library preparation. a Hierarchical clustering of the core microbiome. Hash marks below the dendrogram indicate intrinsic subset designations and SSc clinical diagnosis for each sample. Principal component analysis of the core microbiome was performed to identify associations between microbiome composition and b biopsy location, c clinical diagnosis, and d intrinsic subset