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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs

Fig. 2

Analysis of spontaneous apoptosis in PBMCs purified from patients with RA treated with anti-TNF drugs. a, b Percentage of annexin V (AV)-positive cells by flow cytometry in PBMCs purified from patients with RA (n = 25) before (t0) and after 4 months (t4) of treatment with anti-TNF drugs. Analysis of apoptosis was performed in responders (n = 17) (a) and non-responders (n = 8) (b), separately. Representative dot plots (PI on y-axis vs. AV on x-axis) are also shown, ***P < 0.001. c Correlation and linear regression analysis of autophagy and apoptosis expressed as LC3-II levels and percentage of AV-positive cells, respectively, in PBMCs from patients with RA responding to anti-TNF therapy

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