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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

Fig. 3

Effects of KBP and naproxen on bone resorption and type III collagen degradation. Bone resorption was assessed by CTX-I (a) and type III collagen degradation by MMP-9 was assessed using C3M (b). CIA control n = 6; CIA+KBP n = 5; CIA+KBP+Napr n = 10; CIA+Napr n = 10; sham n = 10. Data are presented as the mean fraction of each rat’s baseline measurement ± SEM using the last observation carried forward for euthanized rats. Asterisk (*) indicates statistical comparisons to CIA control.*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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