Fig. 1
DZ2002 treatment reduced proteinuria and preserved renal function in NZB/WF1 mice. Twenty-four-week-old female NZB/WF1 mice were orally treated with vehicle (H2O), DZ2002 (8 mg/kg, twice a day), and PNS (2 mg/kg) for 15 weeks (n = 9 per group). a Levels of proteinuria. Serum levels of blood urea nitrogen (BUN) (b) and creatinine (c) measured at the end of the experiment. Each dot represented data for individual mouse. d Left: Representative kidney sections stained with H&E (× 200 magnification). Right: Glomerular, interstitial, and vascular pathologic changes were scored from (0) to (4+) as described in the “Methods” section. Statistics results derived from individual mouse of each group (n = 5 per group). Data were shown as the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle