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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

Fig. 4

Functional analysis of significantly changed proteins (SCPs). a PPI network analysis of all the 253 SCPs. b PPI network analysis of SCPs involved in both tight junction pathway and focal adhesion pathway. Actn4 is pointed out by a dashed circle. The gene shape size represents the p value of comparison between model group and drug group by two-tailed Student’s t test in the negative logarithmic scale, ranging from the lowest significance (small) to the strongest (big). The color of each gene represents the ratio of D/V, ranging from the minimum value (green) to the maximum value (red). Disconnected genes are hidden

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