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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

Fig. 7

DZ2002 treatment restrained the elevated ILK expression and β1-integrin phosphorylation in the glomeruli of NZB/WF1 mice. Semi-quantitative measurement of ILK protein and phosphorylated β1-integrin in the kidney form mice of normal, NZB/WF1, and NZB/WF1+DZ2002 group (a and c) and from NZB/WF1 mice of indicated age (b and d). Protein level was measured from the kidney tissue lysate. Each blot represented data for individual mouse (n = 3 per group). Normal, age-matched female C57BL/6 mice; NZB/WF1, vehicle mice in the treatment experiment; and NZB/WF1+DZ2002, DZ2002-treated mice in the treatment experiment. Data were shown as the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 versus NZB/WF1 group or 16-week-old group

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Arthritis Research & Therapy

ISSN: 1478-6362

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