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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

Fig. 8

DZ2002 treatment restored podocyte number in the glomeruli of NZB/WF1 mice. a Left: Representative WT-1 expression in glomeruli by microscopic viewing (× 400 magnification). Right: Quantitative determination of the glomerular WT-1-positive podocyte numbers. Each dot represented data for individual mouse (n = 7 per group). Semi-quantitative measurement of WT-1 in the kidney form mice of normal, NZB/WF1, and NZB/WF1+DZ2002 group (b) and from NZB/WF1 mice of indicated age (disease stage) (c). Protein level was measured from the kidney tissue lysate. Each blot represented data for individual mouse (n = 3 per group). Normal, age-matched female C57BL/6 mice; NZB/WF1, vehicle mice in the treatment experiment; and NZB/WF1+DZ2002, DZ2002-treated mice in the treatment experiment. Data were shown as the mean ± SD. **P < 0.01, ****P < 0.0001 versus NZB/WF1 group or 16-week-old group

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