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Table 1 Baseline clinical characteristics of patients with systemic sclerosis

From: CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan

 

CD34-selected

(n = 11)

Unmanipulated

(n = 8)

p value

Age, years

52.3 ± 7.9

55.8 ± 5.0

0.29

Female, n (%)

8 (73)

7 (88)

0.60

Smokers, n (%)

4 (36)

4 (50)

0.66

Disease duration, median (IQR), years

1.4 (1.2–2.8)

1.2 (0.9–1.7)

0.18

DcSSc with severe skin sclerosis, n (%)

9 (82)

6 (75)

1.00

Modified Rodnan skin score

21.5 ± 9.6

22.9 ± 14.0

0.81

Interstitial pneumonia, n (%)

11 (100)

6 (75)

0.16

Percent predicted FVC

63.1 ± 14.7

83.1 ± 17.3

0.01

Percent predicted DLCO

46.4 ± 17.1

49.8 ± 22.9

0.71

LVEF

70.1 ± 8.0

74.5 ± 6.8

0.29

Anti-Scl70 antibody positive, n (%)

9 (82)

4 (50)

0.32

Previous treatment, n (%)

10 (91)

5 (62.5)

0.26

Corticosteroids, n (%)

10 (91)

5 (62.5)

0.26

Cyclophosphamide, n (%)

4 (36)

3 (38)

1.00

Tacrolimus or cyclosporine, n (%)

3 (27)

2 (35)

1.00

  1. Data are presented as mean ± standard deviation unless otherwise indicated
  2. IQR interquartile range, FVC forced vital capacity, DLCO diffusing capacity of carbon monoxide, LVEF left ventricular ejection fraction