Fig. 5

Identification of rhythmic serum lipid species in RA patients. a Numbers of serum lipid species detected in the three classes. b Number of rhythmic lipid species by class identified in healthy and RA subjects, using a Gaussian process model. c, d The estimated time of peak serum concentration of each rhythmic serum lipid species in healthy and RA. Ceramide peak (pooled CER[NDS]) shown in red. e Circadian profile of CER[A(18)DS(18)] and f 9-HODE in healthy subjects (n = 10) and RA patients (n = 10) respectively. Rhythmicity tested by Gaussian process. P value indicates degree of significance; trend lines included for significant oscillations only. The posterior standard deviation of the mean Gaussian process is shown by the dotted line