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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Fig. 1

CD103+CD4 cDCs are depleted in the spleen of B27-Tg rat. Freshly isolated CD103+ splenic cDCs from 6-month-old NTG and B27-Tg rats were analyzed by flow cytometry. a Representative dot-plots showing the expression of CD4 among CD103+ cDCs. b The graph shows the frequency of CD4 and CD4+ cDCs among CD103+ cDCs in NTG and B27-Tg rats. c The graph shows the absolute numbers of CD4 and CD4+ CD103+ cDCs in NTG and B27-Tg rats. d Representative dot-plots showing live (Annexin V/PI), apoptotic (Annexin V+/PI) and dead (Annexin V+/PI+) cell proportions among CD4 splenic CD103+ cDCs. e, f The graphs show the frequency of apoptotic (Annexin V+/PI) (e) and dead (Annexin V+/PI+) (f) CD4 and CD4+ cDCs in NTG and B27-Tg rats. All experiments were repeated several times, including 8 rats per group. Bars show the mean ± SEM. Data were analyzed by unpaired Student’s t test

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