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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Fig. 2

The frequency of XCR1-expressing CD4 cDCs is decreased in the spleen of B27-Tg rat. ac CD103+cDCs were isolated from the spleen of 6 month-old NTG, B27-Tg, and B7-Tg rats. XCR1 expression was evaluated in CD4 cDCs by flow cytometry (a, b) or by qRT-PCR (c). a Representative dot-plots showing the expression of XCR1 on CD4 CD103+ cDCs in NTG and B27-Tg rats. b The graph shows the frequency of XCR1+ among CD4 CD103+ cDCs in NTG and B27-Tg rats. c The graph shows Xcr1 mRNA levels in purified CD103+CD4 splenic cDCs from NTG, B27-Tg, and B7-Tg rats, expressed in arbitrary units (AU). df CD103+cDCs were isolated from the spleen of 1-month-old NTG and B27-Tg rats. d Representative dot-plots showing the expression of XCR1 among CD4 CD103+ cDCs in NTG and B27-Tg rats. e The graph shows the number of XCR1+ cDCs among CD4 CD103+ cDCs in NTG and B27-Tg rats. f The graph shows the XCR1 mean fluorescence intensity (MFI) staining of XCR1+ CD4 cDCs. Experiments were repeated 4–7 times. Bars show the mean ± SEM. Data were analyzed by unpaired Student’s t test (b, e, f) or one-way ANOVA (c)

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