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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Fig. 4

The proportion of XCR1+CD4− cDCs is decreased in MLN from B27-Tg rats with established disease. Mononuclear cells were isolated from the MLN of NTG and B27-Tg rats at different ages (premorbid: 1 month, established disease: 4–9 months) and analyzed by flow cytometry. a The graph shows the frequency of CD4− among CD103+ cDCs in MLN from NTG and B27-Tg at different ages. b The graph shows the absolute number of CD4− cDCs in MLN from NTG and B27-Tg rats at different ages. c–e XCR1 expression was evaluated among CD4− cDCs by flow cytometry. c Representative dot-plots showing the expression of XCR1 among CD4− CD103+ cDCs in 8-month-old NTG and B27-Tg rats. d The graph shows the frequency of XCR1+ among CD4− CD103+ cDCs in MLN from NTG and B27-Tg rats (e). The graph shows the absolute number of XCR1+ cDCs in MLN from NTG and B27-Tg rats at different ages. Bars show the mean ± SEM. Data were analyzed by unpaired Student’s t test

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Arthritis Research & Therapy

ISSN: 1478-6362

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