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Table 1 Demographic and disease-related characteristics of the population study

From: Deregulation of microRNA expression in monocytes and CD4+ T lymphocytes from patients with axial spondyloarthritis

Variables

Overall population

Exploratory cohort

Replication cohort

Patients

Controls

Patients

Controls

Patients

Controls

No. of cases/controls

81

55

22

17

59

38

Male, n (%)

59 (73)

33 (62)

16 (72)

10 (59)

43 (73)

23 (64)

Age (years)a

40 ± 13

38 ± 8

41 ± 12

39 ± 9

39 ± 13

37 ± 8

Disease duration (years)b

4 (0–46)

 

6.5 (0.2–46)

 

4 (0–44)

 

HLA-B27 positive, n (%)

58 (77)

 

16 (80)

 

42 (76)

 

Current smoker, n (%)

38 (47.5)

 

11 (50)

 

27 (46)

 

Clinical characteristics

 AxSpA, n (%)

78 (97.5)

 

22 (100%)

 

56 (96)

 

 AxSpa X-ray positive, n (%)

56 (70)

 

18 (82)

 

38 (65)

 

 AxSpA MRI positive, n (%)

63 (86)

 

18 (86)

 

45 (87)

 

 Peripheral arthritis

17 (21)

 

6 (27)

 

11 (19)

 

 Enthesitis

40 (50)

 

11 (50)

 

29 (50)

 

 IBD

4 (5)

 

0 (0)

 

4 (7)

 

 Uveitis

28 (35)

 

8 (36)

 

20 (34)

 

 Psoriasis

11 (14)

 

2 (9)

 

9 (16)

 

 Baseline CRP, mg/la

12.5 ± 17

 

15 ± 24

 

12 ± 14

 

 BASDAI M0a

49 ± 19

 

42 ± 18

 

52 ± 19

 

 ASDAS M0a

3 ± 0.9

 

2.9 ± 0.8

 

3 ± 1

 

Treatment

 NSAIDs, last 3 months, n (%)

64 (80)

 

19 (86)

 

45 (78)

 

 Steroids, last 3 months, n (%)

3 (3.75)

 

0 (0)

 

3 (5)

 

 csDMARDS, last 3 months, n (%)

12 (15)

 

7 (32)

 

5 (9)

 

 Methotrexate, n (%)

5 (42)

 

2 (29)

 

3 (60)

 

 Sulfasalazine, n (%)

7 (58)

 

5 (71)

 

2 (40)

 
  1. IBD inflammatory bowel disease, CRP C-reactive protein, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, ASDAS Ankylosing Spondylitis Disease Activity Score
  2. aMean ± SD
  3. bMedian (max-min)