Arthritis Research & Therapy

Table 3 Association between miRs expression and clinical or biological parameters in CD14⁺ and CD4⁺ cells from axSpA patients

From: Deregulation of microRNA expression in monocytes and CD4⁺ T lymphocytes from patients with axial spondyloarthritis

Parameters	CD14⁺			CD4⁺
Parameters	MicroRNA	p value	FDR corrected p value	MicroRNA	p value	FDR corrected p value
Age²	miR-126-3p	4.45E−03	0.05
	miR-574-3p	8.45E−03	0.05
	miR-146a-5p	0.04	0.18
B27	miR-885-5p	0.03	0.46
Male	miR-223-3p	0.03	0.37
Disease duration²	miR-92b-3p	0.03	0.44
Uveitis	miR-92-3p	0.02	0.42	miR-16-5p	0.05	0.49
Psoriasis	miR-15a-5p	0.01	0.10
Psoriasis	miR-484	0.01	0.10
Familial history of SpA	miR-126-3p	0.02	0.18	miR-16-1-3p	0.04	0.39
Familial history of SpA	miR-574-3p	0.03	0.18	miR-16-1-3p	0.04	0.39
Axial involvement				miR-361-3p	0.04	0.28
Peripheral arthritis	miR-16-5p	0.03	0.43	miR-874-3p	0.04	0.45
Elevated CRP¹	miR-146a-5p	1.82E−03	0.02	miR-361-3p	5.76E−03	0.06
Elevated CRP¹	miR-361-3p	0.04	0.29	miR-361-3p	5.76E−03	0.06
CRP value²	miR-92b-3p	1.06E−03	0.01	miR-484	0.04	0.34
	miR-146a-5p	6.64E−03	0.04
	miR-484	0.02	0.09
	miR-574-3p	0.03	0.09
BASDAI > 40	miR-219a-5p	0.03	0.21	miR-874-3p	0.04	0.39
BASDAI > 40	miR-361-3p	0.03	0.21	miR-874-3p	0.04	0.39
BASDAI score²		0.01	0.14
BASDAI score²	miR-361-3p	0.05	0.30
ASDAS score²	miR-146a-5p	5.98E−04	7.78E−03
ASDAS score²	miR-92b-3p	0.01	0.11
Current smoker	let-7b-5p	0.05	0.30	miR-28-5p	0.01	0.11
Current smoker	miR-223-3p	0.05	0.30	miR-28-5p	0.01	0.11
csDMARDS	miR-376a-3p	0.02	0.09
	miR-126-3p	0.02	0.09
	miR-223-3p	0.01	0.09

Only associations with a nominal p value < 0.05 are reported
MicroRNAs with a p value < 0.05 after Benjamin-Hochberg correction are written in italic
¹At least one positive CRP value according to the laboratory reference during the disease course due to the disease’s activity
²Spearman test was used for quantitative values

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