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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells

Fig. 4

Effect of HBO on the mRNA and protein expression of HMGB1, RAGE, and iNOS. a HBO treatment significantly suppressed the mRNA expression of HMGB1 (*p < 0.05; n = 4), RAGE (*p < 0.05; n = 4), and iNOS (*p < 0.05; n = 4) in degenerated NPCs. b Western blot analysis was performed to examine the protein expression of HMGB1, RAGE, and iNOS. The protein expression of HMGB1 (*p < 0.05; n = 3), RAGE (*p < 0.01; n = 3), and iNOS (*p < 0.05; n = 3) were significantly downregulated after culturing for three rounds of HBO treatment. c The quantification of relative protein expression levels

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