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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression

Fig. 4

Romidepsin-induced increased expression of PTEN and CPT1A is independent of cytokine suppression. PBMCs from healthy volunteers or Cowden syndrome patients were pre-incubated for 1 h with several concentrations of romidepsin (Romi) or etomoxir. Cytokine production was induced by adding a combination of 50 μM palmitic acid (C16.0) and 300 μg/mL monosodium urate crystals (MSU). After 24 h, PTEN (a) and CPT1A (b) mRNA expression was determined by qPCR. IL-1β production was measured by ELISA after addition of etomoxir (c) or romidepsin in healthy volunteers and Cowden syndrome patients (d)

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Arthritis Research & Therapy

ISSN: 1478-6362

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