Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives

Idborg, Helena; Zandian, Arash; Sandberg, Ann-Sofi; Nilsson, Bo; Elvin, Kerstin; Truedsson, Lennart; Sohrabian, Azita; Rönnelid, Johan; Mo, John; Grosso, Giorgia; Kvarnström, Marika; Gunnarsson, Iva; Lehtiö, Janne; Nilsson, Peter; Svenungsson, Elisabet; Jakobsson, Per-Johan

doi:10.1186/s13075-019-1836-8

Table 2 Affinity-based proteomics results comparing aPL+ SLE (n = 66) vs SSA/SSB+ SLE (n = 63) subgroup. The proteins with the lowest p values comparing the two suggested subgroups are shown

From: Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives

Gene	Uniprot ID	Protein name	Protein function¹	p value ²aPL+ vs SSA/SSB+ SLE	Fold change³ SSA/SSB+ vs. aPL+ SLE
ITGB1	P05556	Integrin beta-1	Cell adhesion, host-virus interaction, integrin	1.90E−10	3.4
SLC13A3	Q8WWT9	Solute carrier family 13 member 3	Ion transport, sodium transport	2.20E−08	2.3
CERS5	Q8N5B7	Ceramide synthase 5	Lipid biosynthesis/metabolism, sphingolipid metabolism	2.70E−08	2.7
MSX2	P35548	Homeobox protein MSX-2	Osteogenesis, transcription, transcription regulation	2.80E−08	1.5
F3	P13726	Tissue factor. Coagulation factor III	Blood coagulation, hemostasis	3.60E−08	1.7
HSP90AA1	P07900	Heat shock protein HSP 90-alpha	Stress response, chaperon	5.00E−08	2.6
MMP8	P22894	Neutrophil collagenase. Metalloproteinase 8	Collagen degradation	5.40E−08	2.1
CTSB	P07858	Cathepsin B	Thiol protease	6.10E−08	1.3
MMP10	P09238	Stromelysin-2	Collagen degradation	1.30E−07	1.9
YARS	P54577	Tyrosine--tRNA ligase	Protein biosynthesis, aminoacyl-tRNA synthetase	5.30E−07	2.1
SELE	P16581	E-selectin	Cell adhesion	7.70E−07	2.4
FMO1	Q01740	Dimethylaniline monooxygenase [N-oxide-forming] 1	Catalyzes the N-oxygenation of secondary and tertiary amines	9.90E−07	1.8
SAMD8	Q96LT4	Sphingomyelin synthase-related protein 1	Lipid metabolism, sphingolipid metabolism	3.40E−06	2.1
ETNPPL	Q8TBG4	Ethanolamine-phosphate phospho-lyase	Aminotransferase, lyase, transferase	5.70E−06	1.3
ARID2	Q68CP9	AT-rich interactive domain-containing protein 2. BAF200	Transcription, transcription regulation, chromatin regulator	8.90E−06	1.9
ETV7	Q9Y603	Transcription factor ETV7	Repressor	1.20E−05	1.4
CD40	P25942	Tumor necrosis factor receptor superfamily member 5. B-cell surface antigen CD40	Receptor for TNFSF5/CD40LG	1.50E−05	1.6
KRT7	P08729	Keratin. type II cytoskeletal 7	Viral process, blocks interferon-dependent interphase and stimulates DNA synthesis in cells	4.10E−05	0.8
TYK2	P29597	Non-receptor tyrosine-protein kinase TYK2	Kinase, transferase, tyrosine-protein kinase	6.70E−05	1.4
REN	P00797	Renin. Angiotensinogenase	Aspartyl protease, hydrolase, protease	7.30E−05	1.4
APCS	P02743	Serum amyloid P-component	DNA-binding and opsonizing protein	9.10E−05	0.9
CYR61	O00622	Insulin-like growth factor-binding protein 10	Growth factor binding, heparin-binding	0.00013	0.9
CLDN16	Q9Y5I7	Claudin 16	Ion transport, transport	0.00014	1.7
GOT1	P17174	Aspartate aminotransferase	Aminotransferase, transferase	0.00017	1.3
EGF	P01133	Pro-epidermal growth factor	Growth factor	0.00027	1.2

¹Protein function/biological process according to www.uniprot.org [54]
²p value obtained by Wilcoxon rank-sum test and Bonferroni correction for multiple testing
³Fold change is reported comparing the two subgroups. Values above 1 means upregulated in the SSA/SSB+ subgroup and values below 1 that the protein was downregulated in the SSA/SSB+ subgroup. Mean fold change of more than 100% is highlighted in italics

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ISSN: 1478-6362

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