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Table 2 Affinity-based proteomics results comparing aPL+ SLE (n = 66) vs SSA/SSB+ SLE (n = 63) subgroup. The proteins with the lowest p values comparing the two suggested subgroups are shown

From: Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives

Gene Uniprot ID Protein name Protein function1 p value 2aPL+ vs SSA/SSB+ SLE Fold change3 SSA/SSB+ vs. aPL+ SLE
ITGB1 P05556 Integrin beta-1 Cell adhesion, host-virus interaction, integrin 1.90E10 3.4
SLC13A3 Q8WWT9 Solute carrier family 13 member 3 Ion transport, sodium transport 2.20E08 2.3
CERS5 Q8N5B7 Ceramide synthase 5 Lipid biosynthesis/metabolism, sphingolipid metabolism 2.70E08 2.7
MSX2 P35548 Homeobox protein MSX-2 Osteogenesis, transcription, transcription regulation 2.80E08 1.5
F3 P13726 Tissue factor. Coagulation factor III Blood coagulation, hemostasis 3.60E08 1.7
HSP90AA1 P07900 Heat shock protein HSP 90-alpha Stress response, chaperon 5.00E08 2.6
MMP8 P22894 Neutrophil collagenase. Metalloproteinase 8 Collagen degradation 5.40E08 2.1
CTSB P07858 Cathepsin B Thiol protease 6.10E08 1.3
MMP10 P09238 Stromelysin-2 Collagen degradation 1.30E07 1.9
YARS P54577 Tyrosine--tRNA ligase Protein biosynthesis, aminoacyl-tRNA synthetase 5.30E07 2.1
SELE P16581 E-selectin Cell adhesion 7.70E07 2.4
FMO1 Q01740 Dimethylaniline monooxygenase [N-oxide-forming] 1 Catalyzes the N-oxygenation of secondary and tertiary amines 9.90E07 1.8
SAMD8 Q96LT4 Sphingomyelin synthase-related protein 1 Lipid metabolism, sphingolipid metabolism 3.40E06 2.1
ETNPPL Q8TBG4 Ethanolamine-phosphate phospho-lyase Aminotransferase, lyase, transferase 5.70E06 1.3
ARID2 Q68CP9 AT-rich interactive domain-containing protein 2. BAF200 Transcription, transcription regulation, chromatin regulator 8.90E06 1.9
ETV7 Q9Y603 Transcription factor ETV7 Repressor 1.20E05 1.4
CD40 P25942 Tumor necrosis factor receptor superfamily member 5. B-cell surface antigen CD40 Receptor for TNFSF5/CD40LG 1.50E05 1.6
KRT7 P08729 Keratin. type II cytoskeletal 7 Viral process, blocks interferon-dependent interphase and stimulates DNA synthesis in cells 4.10E05 0.8
TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 Kinase, transferase, tyrosine-protein kinase 6.70E05 1.4
REN P00797 Renin. Angiotensinogenase Aspartyl protease, hydrolase, protease 7.30E05 1.4
APCS P02743 Serum amyloid P-component DNA-binding and opsonizing protein 9.10E05 0.9
CYR61 O00622 Insulin-like growth factor-binding protein 10 Growth factor binding, heparin-binding 0.00013 0.9
CLDN16 Q9Y5I7 Claudin 16 Ion transport, transport 0.00014 1.7
GOT1 P17174 Aspartate aminotransferase Aminotransferase, transferase 0.00017 1.3
EGF P01133 Pro-epidermal growth factor Growth factor 0.00027 1.2
  1. 1Protein function/biological process according to [54]
  2. 2p value obtained by Wilcoxon rank-sum test and Bonferroni correction for multiple testing
  3. 3Fold change is reported comparing the two subgroups. Values above 1 means upregulated in the SSA/SSB+ subgroup and values below 1 that the protein was downregulated in the SSA/SSB+ subgroup. Mean fold change of more than 100% is highlighted in italics