|
Characteristics associated to HRQoL
|
EA
|
Early IBP
|
|---|
|
MCS beta (p value)
|
PCS beta (p value)
|
MCS beta (p value)
|
PCS beta (p value)
|
|---|
|
Baseline characteristics
|
|
Age
|
− 0.0049 (0.055)
|
− 0.0086 (0.001)
|
− 0.00031 (0.69)
|
− 0.0017 (0.003)
|
|
Gender
|
− 0.0056 (0.93)
|
+ 0.041 (0.50)
|
+ 0.00075 (0.96)
|
+ 0.016 (0.12)
|
|
Level of studies
|
− 0.029 (0.66)
|
+ 0.20 (0.003)
|
− 0.013 (0.33)
|
+ 0.017 (0.11)
|
|
Level employment
|
+ 0.017(0.82)
|
+ 0.12 (0.04)
|
+ 0.026 (0.06)
|
− 0.010 (0.32)
|
|
Baseline MCS-SF36
|
− 0.041 (< 0.001)
|
+ 0.0012 (0.007)
|
− 0.0083 (< 0.001)
|
+ 0.0013 (0.004)
|
|
Baseline PCS-SF36
|
− 0.0048 (0.19)
|
− 0.038 (< 0.001)
|
− 0.00001 (0.99)
|
− 0.0052 (< 0.0001)
|
|
Smoking status
|
− 0.097 (0.11)
|
− 0.049 (0.33)
|
+ 0.0058 (0.68)
|
+ 0.0077 (0.46)
|
|
HLAB27 status
|
NA
|
NA
|
+ 0.011 (0.42)
|
− 0.0062 (0.54)
|
|
Radiological or MRI sacroiliitis
|
NA
|
NA
|
− 0.012 (0.39)
|
+ 0.016 (0.12)
|
|
Symptom duration
|
+ 0.0012 (0.04)
|
+ 0.0025 (< 0.001)
|
+ 0.0062 (0.42)
|
− 0.015 (0.008)
|
|
Variables changing over time
|
|
Erosions on hands and/or feet
|
+ 0.54 (0.19)
|
+ 0.32 (0.36)
|
NA
|
NA
|
|
Oral corticosteroid
|
+ 0.13 (0.10)
|
+ 0.20 (0.002)
|
NA
|
NA
|
|
DMARDs
|
+ 0.36 (< 0.001)
|
+ 0.61 (< 0.001)
|
NA
|
NA
|
|
DAS28-ESR/ASDAS-CRP
|
+ 0.20 (< 0.001)
|
+ 0.27 (< 0.001)
|
+ 0.0062 (0.39)
|
− 0.016 (0.0005)
|
|
Extra articular manifestations†
|
NA
|
NA
|
− 0.0037 (0.80)
|
+ 0.00001 (1.00)
|
|
Peripheral arthritis
|
NA
|
NA
|
+ 0.029 (0.04)
|
+ 0.018 (0.09)
|
|
Enthesitis
|
NA
|
NA
|
+ 0.014 (0.36)
|
+ 0.015 (0.19)
|
|
TNFi
|
NA
|
NA
|
− 0.021 (0.21)
|
− 0.027 (0.03)
|
- DAS28-CRP was applied to EA and ASDAS-CRP to early IBP
- MCS mental composite score, PCS physical composite score, ASDAS-CRP Ankylosing Spondylitis Disease Activity Score—C reactive protein, DAS28-ESR Disease Activity Score 28—erythrocyte sedimentation rate, TNFi tumor necrosis factor inhibitor, NA not analysed
- †Extra-articular manifestations including uveitis, psoriasis or inflammatory bowel disease
