What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

Table 3 Results of logistic regression for RA development in undifferentiated arthritis patients

	Patients with MRI feature, n (%)		Univariable analyses		Multivariable analyses: types of MRI inflammation^b		Multivariable analysis: presence of tenosynovitis adjusted for SJC and CRP^b
	RA	No RA	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Foot (MTPs)^a
Presence of:
Tenosynovitis	18 (29)	8 (14)	2.55 (1.01–6.43)	0.047	3.29 (1.03–10.53)	0.045	2.14 (0.77–5.95)	0.14
Synovitis	14 (22)	10 (17)	1.40 (0.57–3.45)	0.47	0.96 (0.30–3.10)	0.95
BME	6 (9)	11 (19)	0.44 (0.16–1.31)	0.14	0.33 (0.10–1.09)	0.068
Hand (MCPs and wrist)^a
Presence of:
Tenosynovitis	46 (72)	24 (41)	3.73 (1.76–7.91)	0.001	3.99 (1.64–9.69)	0.002	2.36 (1.04–5.38)	0.041
Synovitis	28 (44)	18 (31)	1.77 (0.84–3.72)	0.13	1.04 (0.41–2.67)	0.94
BME	21 (33)	24 (41)	0.71 (0.34–1.49)	0.37	0.57 (0.25–1.29)	0.18
Swollen joints, per joint			1.46 (1.20–1.79)	< 0.001
Elevated CRP			2.77 (1.23–6.23)	0.014

SJC swollen joint count (66 swollen joint counts were performed), CRP C-reactive protein, RA rheumatoid arthritis, OR odds ratio, CI confidence interval, MTP metatarsophalangeal joint, MCP metacarpophalangeal joint, BME bone marrow edema
^aAt joint level, a score was considered abnormal for BME, synovitis or tenosynovitis if the scores of both readers at the same location were present in < 5% of symptom-free persons of the same age category (18–40, 40–60 or > 60 years). At patient level, BME, synovitis and tenosynovitis were considered present if ≥ 1 joint of foot or hand was positive
^bMultivariable analyses were performed for the foot and for the hand separately

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