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Table 1 Baseline characteristics of patients included in the study

From: Association between concomitant csDMARDs and clinical response to TNF inhibitors in overweight patients with axial spondyloarthritis

Characteristics

Total patients (n = 246)

Included patients (n = 180)

Included patients BMI ≤ 25 (n = 78)

Included patients BMI > 25 (n = 102)

Age (years)

47.6 ± 13.1

47.0 ± 12.7

42.9 ± 11.7

50.1 ± 12.6***

Male

146 (59)

107 (59)

39 (50)

68 (67)*

Disease duration (years)

10 (5–16)

8 (5–16)

7 (3–13)

9 (6–18)**

SpA subtype

 Ankylosing spondylitis

179 (78)

140 (78)

64 (82)

76 (74)

 Non-radiographic SpA

49 (22)

40 (22)

14 (18)

26 (26)

HLA-B27

174 (74)

131 (73)

61 (78)

70 (69)

Psoriasis/IBD/uveitis

71 (29)

58 (32)

27 (35)

31 (30)

Peripheral arthritis

97 (40)

86 (48)

38 (49)

48 (47)

BASDAI

5.8 ± 2.0

5.8 ± 2.0

5.5 ± 2.1

6.0 ± 1.9

ASDAS

3.3 ± 0.9

3.3 ± 1.0

3.2 ± 1.0

3.4 ± 1.0

ESR (mmHg)

17 (7–33)

17 (7–31)

19 (6–34)

16 (7–31)

CRP (mg/L)

5 (2–15)

6 (3–17)

7 (2–20)

5 (3–15)

Previous TNFi

43 (18)

35 (19)

13 (17)

22 (21)

TNFi type

 Infliximab

107 (43)

74 (41)

25 (32)

49 (48)*

 Adalimumab

139 (57)

106 (59)

53 (68)

53 (52)*

csDMARD

 Any csDMARD

102 (42)

79 (44)

31 (40)

48 (47)

 MTX

34 (15)

25 (14)

12 (15)

13 (13)

 SSZ

46 (21)

36 (20)

10 (13)

26 (25)*

 MTX and SSZ

22 (9)

18 (10)

9 (11)

9 (9)

Prednisone

22 (9)

20 (11)

11 (14)

9 (9)

  1. The table shows mean ± SD, median (IQR) or absolute number (percentage) for all patients included (n = 180). The results are also stratified by body mass index (BMI). p value < 0.05 was considered statistically significant. Significant statistical differences between the groups of included patients, stratified by BMI: *p < 0.05, **p < 0.01, ***p < 0.001. SpA spondyloarthritis, HLA-B27 human leucocyte antigen B27, ESR erythrocyte sedimentation rate, CRP C-reactive protein, IBD inflammatory bowel disease, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, ASDAS Ankylosing Spondylitis Disease Activity Index, TNFi tumour necrosis factor inhibitors, csDMARD conventional synthetic disease-modifying anti-rheumatic drug, MTX methotrexate, SSZ sulfasalazine