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Table 1 Characteristics of patients diagnosed with CTD and IM

From: Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors

Characteristics SLE (n = 19) AAV (n = 7) PM/DM (n = 3) RA (n = 2) SSc (n = 1)
Demographic characteristics
 Sex, male to female 5:14 1:6 1:2 0:2 0:1
 Age, years, mean ± SD 35.6 ± 15.3 53.1 ± 13.0 57.0 ± 4.4 46.5 ± 9.2 46.0
 Duration of CTD, months, median (IQR) 4(1.0,21.0) 3(0.3,84.0) 120(61.5,180.0) 204(186.0,222.0) 108.0
 Diabetes mellitus, n (%) 3(15.8) 1(14.3) 0(0) 0(0) 0(0)
 Nephritis, n (%) 15(78.9) 4(57.1) 0(0) 0(0) 0(0)
 Interstitial pneumonia, n (%) 1(5.3) 3(42.9) 1(33.3) 0(0) 1(100.0)
Laboratory data
 WBC count (× 109), mean ± SD 9.5 ± 6.7 10.7 ± 6.0 12.9 ± 5.6 8.8 ± 1.2 6.6
 Lymphocyte count (× 109), mean ± SD 0.9 ± 1.0 0.8 ± 0.7 1.1 ± 0.4 1.5 ± 1.0 0.7
 Hemoglobin (g/l), mean ± SD 96.1 ± 26.2 87.3 ± 27.5 116.7 ± 2.5 114.5 ± 3.5 109.0
 Serum albumin (g/l), mean ± SD 28.1 ± 7.4 32.8 ± 3.5 27.0 ± 11.3 35.5 ± 4.9 32.0
 Elevated serum creatinine, n (%) 6(31.6) 6(85.7) 0(0) 0(0) 0(0)
 IgM (g/l), median (IQR) 0.7(0.3,0.9) 0.5(0.4,0.8) 1.2(1.1,1.4) 0.7(0,0.5) 0.3
 IgG (g/l), median (IQR) 15.4(7.4,17.4) 13.4(12.6,20.4) 15.2(14.4,16.0) 14.8(0,11.8) 14.1
 ESR (mm/h),median (IQR) 45.0(39,58.5) 63.0(60,66.0) 87.5(81.8,93.3) 49.5(43.3,55.8) 30.0
 CRP (mg/l), median (IQR) 11.0(6.2,33.4) 12.3(6.3,20.1) 102.0(52.7,139.0) 65.6(34.4,96.8) 0.6
Treatment prior to IM
 Median-to-high dose of GC, n (%) 6(31.6) 3(42.9) 2(66.7) 0(0) 0(0)
 CYC, n (%) 4(21.1) 4(57.1) 1(33.3) 0(0) 0(0)
 MMF, n (%) 3(15.8) 0(0) 0(0) 0(0) 0(0)
 CsA, n (%) 2(10.5) 0(0) 0(0) 1(50.0) 0(0)
 MTX, n (%) 1(5.3) 0(0) 0(0) 1(50.0) 0(0)
  1. AAV ANCA-associated vasculitis, CRP C-reactive protein, CsA cyclosporine A, CTD connective tissue disease, CYC cyclophosphamide, ESR erythrocyte sedimentation rate, GC glucocorticoid, IM invasive mycoses, IQR interquartile range, MMF mycophenolate mofetil, MTX methotrexate, PM/DM polymyositis/dermatomyositis, RA rheumatoid arthritis, SD standard deviation, SLE systemic lupus erythematosus, SSc systemic sclerosis, WBC white blood cell