Fig. 6
From: Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis
Antiarthritic effects of Lonidamine on collagen-induced arthritis. Clinical severity (a) and hind paw thickness (b) of CIA following treatment with LND or its vehicle. Clinical scores and hind paw thickness were monitored daily for 3 weeks after the booster injection (n = 10 per group). c Paw photographs obtained on day 42 from mice with CIA treated with vehicle or LND. The symptoms of CIA were observed in the hind paws of these collagen-treated mice as indicated treatments. d Photomicrographs show ankle joints were harvested on day 21 after the second immunization, sectioned, and stained with hematoxylin and eosin. Synovial hyperplasia (red arrow), immune cell infiltration (blue arrow), and bone destruction (yellow arrow) can be seen. Serum levels of anti-CII IgG1 (e), IgG2a (f), and IgG2b (g) in the CIA mice treated with vehicle or LND were measured by ELISA on days 7, 14, and 21 after the booster immunization. The statistical significances of differences between LND treated group and vehicle group were determined. Data represent the mean ± SE. *p < 0.05significantly different