Table 4 HRs (95% CI) for univariate and multivariable Cox regression models of time to death
Variable | Models | |||
|---|---|---|---|---|
Univariate | Multivariable | |||
HR (95% CI) | p | HR (95% CI) | p | |
Age at first symptom (5-year increase) | 1.28 (1.07–1.52) | 0.007 | 1.36 (1.14–1.62) | < 0.001 |
E2 level (10-pg/mL increase) | 1.18 (1.01–1.39) | 0.042 |  | 0.555 |
Scl-70 status (yes) | 1.77 (0.86–3.65) | 0.124 |  | 0.006 |
Age at first symptom × Scl-70 |  |  |  | < 0.001 |
 Scl-70 yes vs. no (at 25th percentile E2 level (17.4)) |  |  | 0.16 (0.03–1.01) |  |
 Scl-70 yes vs. no (at 50th percentile E2 level (25.8)) |  |  | 0.48 (0.12–1.89) |  |
 Scl-70 yes vs. no (at 75th percentile E2 level (40.8)) |  |  | 3.47 (1.47–8.19) |  |
 10-pg/mL increase in E2 level (for Scl-70 positive) |  |  | 3.95 (2.08–7.49) |  |
 10-pg/mL increase in E2 level (for Scl-70 negative) |  |  | 1.06 (0.87–1.29) |  |