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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis

Fig. 2

Iguratimod regulates major transcript factor (TF) network of ASC differentiation. Human B cells were stimulated by CpG/IL-2/IL-10 in the presence of vehicle (DMSO) or 10 μM iguratimod and harvested on day 4. a Gene expressions of BLIMP1, XBP1, and PAX5 were quantified by qRT-PCR (n = 6). b BLIMP1, XBP1, and PAX5 were measured by flow cytometry, and c cumulative data of positive frequencies and median fluorescence intensities (MFI) of individual TFs were also shown (n = 5). One representative of at least three independent experiments was shown. Data were analyzed by paired Student’s t test (a and c). *P < 0.05, **P < 0.01

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