Fig. 3

Iguratimod is unlikely to inhibit ASC differentiation via COX-2. Human B cells were stimulated by CpG/IL-2/IL-10 in the presence of vehicle (DMSO), 10 μM celecoxib, or 10 μM iguratimod (a) or as indicated (b) for 5 days. a Representative FCM plots and b cumulative data of a were shown (n = 4). One representative of at least three independent experiments was shown. Data were expressed as mean ± SEM and analyzed by one-way ANOVA with Bonferroni correction for multiple comparisons (b). *P < 0.05, **P < 0.01, ****P < 0.0001